Breast Cancer Prevention

Phase IIIb Comparison of BARACLUDE

Phase IIIb Comparison of BARACLUDE® (entecavir) Monotherapy versus BARACLUDE plus Tenofovir Combination Shows No Statistical Difference Between Study Arms

San Francisco, CA (PRWEB) November 09, 2011

Bristol-Myers Squibb Company (NYSE: BMY) today announced 96-week results from the BE‐LOW™ study, a Phase IIIb clinical trial comparing BARACLUDE monotherapy (0.5mg once daily) with BARACLUDE (0.5mg once daily) plus tenofovir (300mg once daily) in treatment-naïve adult patients with HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB) with compensated liver disease. In this study, no statistically significant difference was observed between the two treatment arms in the primary efficacy endpoint of HBV DNA

“In these 96-week data comparing entecavir monotherapy to combination of entecavir plus tenofovir, we found that combination therapy did not result in statistically significant difference in virologic response compared to entecavir monotherapy. The BE-LOW study data confirmed the results of previous studies showing limited or no benefit of combination therapy compared to monotherapy for treatment-naïve patients with chronic hepatitis B,” said principal investigator Anna Lok, MD, FRCP, director of clinical hepatology and professor in the department of internal medicine at the University of Michigan Medical School in Ann Arbor.

Study Results

In this study, 379 nucleos(t)ide-naïve patients with CHB were randomized to receive either BARACLUDE (entecavir) 0.5 mg once daily (n=182) or BARACLUDE 0.5 mg plus tenofovir 300 mg once daily (n=197). Key findings at week 96 are:

A comparable proportion of patients in both treatment arms achieved the primary efficacy endpoint of HBV DNA
Among HBeAg-positive patients, the proportion achieving HBV DNA
Among HBeAg-negative patients, the proportion achieving HBV DNA

Secondary efficacy endpoints measured in the study included alanine aminotransferase (ALT) normalization, HBeAg seroconversion, and HBeAg loss. ALT normalization was observed in 81.9% (149/182) of patients in this study in the BARACLUDE (entecavir) monotherapy arm versus 69% (136/197) in the BARACLUDE plus tenofovir arm. HBeAg seroconversion was observed in 32.5% (41/126) of patients in the BARACLUDE (entecavir) monotherapy arm versus 21.7% (30/138) in the BARACLUDE plus tenofovir arm in this study.

Two patients (1.1%) in the BARACLUDE monotherapy arm compared to five patients (2.5%) in the BARACLUDE plus tenofovir arm discontinued treatment prior to week 96. Patients who discontinued therapy prior to week 96 were considered treatment failures.

The overall adverse event profiles were similar across study arms. A total of three deaths occurred among treated patients, all on the BARACLUDE plus tenofovir arm: one due to bile duct tumor; one due to a late-onset exacerbation of hepatitis which was associated with breakthrough viremia while on continued treatment; and one due to cardiac arrest. One patient (0.5%) in the BARACLUDE monotherapy arm and two patients (1.0%) in the BARACLUDE plus tenofovir arm experienced on treatment ALT flares, defined as greater than 2 x baseline ALT and greater than 10 x ULN. No patients (0.0%) in either arm experienced off-treatment ALT flares. Six patients (3.3%) in the BARACLUDE monotherapy arm and four (2.0%) patients in the BARACLUDE plus tenofovir arm experienced serum creatinine increase ≥0.3 mg/dL. A total of five malignancies occurred among patients in the study: four (2.2%) patients in the BARACLUDE monotherapy arm and one (0.5%) patient in the BARACLUDE plus tenofovir arm. In the BARACLUDE monotherapy arm, there were three diagnoses of hepatocellular carcinoma (two on-treatment and one off-treatment) and one case of gastric cancer. In the BARACLUDE plus tenofovir arm there was one case of breast cancer.

Two patients (1.0%) in the BARACLUDE monotherapy arm and seven patients (3.6%) in the BARACLUDE plus tenofovir arm experienced virologic breakthrough. No recognized genotypic resistance mutations were observed in either treatment arm.

About The Study

The BE-LOW study is an open-label, multicenter, Phase IIIb study of 379 nucleos(t)ide-naïve patients with CHB. The patients were randomized 1:1 and treated with either BARACLUDE 0.5 mg once daily (n=182) or BARACLUDE 0.5 mg plus tenofovir 300 mg once daily (n=197). Nucleos(t)ide-naïve, HBeAg-negative CHB patient enrollment was capped at 30%. The primary efficacy endpoint was the proportion of patients with HBV DNA

About Chronic Hepatitis B

Approximately 350 million people worldwide are chronically infected with hepatitis B (approximately 5% of the world’s population) and 75% of these cases occur in the Asia-Pacific region.(2) Most people with chronic hepatitis B show no signs or symptoms, so many of those chronically infected are unaware of their status. A blood test can diagnose chronic hepatitis B. Patients should speak with their doctor about options available for this condition.

About BARACLUDE®

Discovered at Bristol-Myers Squibb, BARACLUDE® is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults with:

compensated liver disease and evidence of active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active inflammation and/or fibrosis

decompensated liver disease

For full prescribing information for BARACLUDE®, please consult the Summary of Product Characteristics.

About Bristol-Myers Squibb

Bristol-Myers Squibb is a global biopharmaceutical company committed to discovering, developing and delivering innovative medicines that help patients prevail over serious diseases.

BARACLUDE® (entecavir) is a registered trademark of Bristol-Myers Squibb Company.

Contacts:             

Bristol-Myers Squibb

Media: Annie Simond, +33 1 58 83 65 66, annie.simond(at)bms(dot)com

Note:

(1) HBV DNA carries the genetic blueprint of the hepatitis B virus. The number of HBV DNA “copies” found in a person’s blood, or “viral load,” indicates how rapidly the virus is reproducing in their liver. Low levels of HBV DNA, recognized as 300 copies per milliliter or less, indicate an “inactive” hepatitis B infection.

Reference:

(2) Hou J, Liu Z, Gu F. Epidemiology and Prevention of Hepatitis B Virus Infection. Int J Med Sci 2005; 2:50 – 57. Available from http://www.medsci.org/v02p0050.htm Accessed November 2011

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Powerful Antioxidants For Breast Cancer Prevention and Healing

by calvinfleming

Powerful Antioxidants For Breast Cancer Prevention and Healing

Do you know foreign bodies attack your body every day? These foreign bodies or molecules are known as free radicals. They are known as free radicals because they have lost an electron and thus are roaming freely about with no attachment to an atom. However, the first atom they find they will become attached to it. Once they become attached to the atom, the cell destroys what is there, or replaces the cell. When this replacement has been completed, the once healthy cell now becomes a bad cell. Then the bad cell goes after another healthy cell and converts that cell into a bad cell. In time, these groups of cells become mutated and cancerous. This is how you can get any type of cancer, including the breast cancer.

In order to reverse this process, you need to have an adequate supply of antioxidants such as fruits, vegetables, and other foods. The three most powerful antioxidants are beta-carotene, vitamin C, and vitamin E. This powerful antioxidants can heal you to prevent the breast cancer and also cure it.

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Beta-carotene is what gives many fruits their appearance. It also stimulates the release of natural killer cells, which hunt down and destroy cancer cells before they can do any damage. It only takes about 15 to 30 milligrams a day to stop these free radicals and destroy them. You can find beta-carotene in cantaloupes, sweet potatoes, spinach, and Chinese cabbage.

Vitamin C is the next powerful antioxidant. According to scientific studies at the University of California, those who took at least 66 milligrams of vitamin C every day, found their bodies to be free of any foreign antibodies.

The most versatile antioxidant is vitamin E. This vitamin not only blocks free radicals, it also stops cancer by stimulating the immune system. When the immune system is engaged, it goes about its job of destroying any bad cells in the body.

The best way to get vitamin E is by eating wheat germ. Other foods that contain vitamin E are whole grains, legumes, nuts, and seeds.

The breast cancer can be cured and prevented. Just believe it. It is possible. It has been done before.

I want to aware all the women and men about the danger of this disease, but to help all the people, including man, who go it. Read the short information about how can be prevented and healed. Fill the form, in order to receive some free articles about breast cancer healing and prevention. http://www.breastcancerhealingtips.com/squeeze.html

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Everyone Shuold Know About Breast Cancer Prevention

Breast menaced prevention is important for women to learn about, especially since breast tumor is the most generally occurring progress in women. The American Cancer Society’s web location hearsay that over two-hundred thousand women were diagnosed with this disease in 2006 and there are over two million women in the United States who have normal cure for breast plague. With facts this staggering, preventing melanoma should be a priority for all women.

The first and easiest step in breast pest prevention knows what you are up against. This means knowledge all about the danger factors that may touch you. Family annals and genetic make-up are two danger factors women cannot direct, but must be attentive of when it comes to prevention. If your mother, grandmother or even sister has been diagnosed with breast canker, your risks go up too.

The choices you make in life also become peril factors. Women who take oral contraceptives could have a larger hazard of developing this deadly disease. Having children before the age of thirty can put women at a senior menace for breast bane. Although some expose factors are easier to charge than others, familiarizing oneself with masses of information will only make fighting scourge easier for you.

There are certain medications presented to women who reduction under high gamble factors for breast melanoma. The drug Tamoxifen has been worn in the United States for over twenty-five being to help in the wrangle for breast blight prevention. The drug is taken once daily as a pill and interferes with the female hormone estrogen, preventing it from attaching itself to cells in the breast hankie.

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This medication could also be used to doctor women already diagnosed with breast scourge because it can dense down or determine the growth of cancerous cells. Tamoxifen has even been associated with serving inhibit a recurrence in women who previously suffered from breast evil.

A more mutual way to foil breast bane is through mammograms. A mammogram is a x-ray of the breast and is the most universal form of prevention. Women who are over forty existence of age should get mammograms on a yearly beginning. For women in their twenty’s and thirty’s, the American Cancer Society’s web location recommends getting clinical breast exams at least every three years from a remedial professional.

This suffering is performed using the tips of the fingers to confirm the whole breast matter and under the arm. Besides mammograms and clinical breast exams, women should also stage breast self exams each month to identify any symbols of lumps or abnormalities in the hankie.

The Center for Disease Control (CDC) is able to help women who accident within the lessen poverty levels, are uninsured or underserved profit access to screenings for breast bane. This planned is called the National Breast and Cervical Cancer Early Detection Program. The CDC’s web site touts it has served more than two million women under this plan since its start in 1991.

In 2000, Congress expanded this examine by hole it up to women who are on Medicaid. This breast pest hegemony act, formally posh the Breast and Cervical Cancer Prevention and Treatment Act, is a way to help women, who may have little access to worth fitness care, have a prospect at breast and cervical growth prevention.

For everyone who has suffered from breast blight, maintaining prevention is critical. It should be just as important for those who never have experienced this disease. Breast canker prevention is about education you’re genetic make-up and if somebody in your family suffered from cancer.

Prevention is also about making healthier lifestyle choices by intake right, exercising and avoiding cigarettes. Be smart and make the right decisions to ensure you will have a long and healthful life.

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The new research is working on some chemical agents that may prevent the production of C35 protein. The test results in their initial stages have been positive, but the formulation of a drug for human consumption is still some time away. It is critical to reach a chemical agent that works without causing any harm to the human body, which is the main thrust of the research.

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Sources:

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Urdu Breast Cancer Preventable ?

by Joelk75

Urdu Breast Cancer Preventable ?

Breast-feeding needs to be encouraged and late pregnancy avoided. Unfortunately most women (60%) are present in stage III and IV of the disease, when cure is impossible. These women would have escaped the dreadful course of cancer, the cost of treatment and death if the cancer was detected early. As many as 21 % of women who develop breast cancer, die within the first year of diagnosis.when cure is impossible. These women would have escaped the dreadful course of cancer, the cost of treatment and death if the cancer was detected early. As many as 21 % of women who develop breast cancer, die within the first year of diagnosis.

Beauty tips in urdu

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Health Tips For Women

The detection of breast cancer in its initial stages when small and before it has had the chance to spread, and its treatment with available options can achieve cure. This aim can be achieved by screening women with identifiable risk factors. Women are motivated to self examine their breasts (breast self examination BSE) and a periodic physical examination can be carried out by the family doctor or a health visitor, in high risk women. The acceptance of this simple and inexpensive screening method, however, may not be easy, since most women are either illiterate or live under constant stress of daily life.may not be easy, since most women are either illiterate or live under constant stress of daily life.

Mammography for screening of asymptomatic women is a useful test. It can be done every 1-2 years, especially among high risk women. It greatly helps in discovering early lesions, especially among women over 50. Abnormalities detected on screening are impalpable and can be subjected to image guided fine needle aspiration cytology for diagnosis.Mammography for screening of asymptomatic women is a useful test. It can be done every 1-2 years, especially among high risk women. It greatly helps in discovering early lesions, especially among women over 50. Abnormalities detected on screening are impalpable and can be subjected to image guided fine needle aspiration cytology for diagnosis.

Indeed, there is anxiety amongst women when invited for breast screening, but once motivated, after a few visits when no abnormality is discovered; they become more keen and regular.

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What are the causes, symtoms and prevention for breast cancer?

by Ron Sombilon Gallery

Question by niyi: What are the causes, symtoms and prevention for breast cancer?

Best answer:

Answer by Cinderella
Breast cancer is a cancer that starts in the cells of the breast in men and women.[1] Worldwide, breast cancer is the second most common type of cancer after lung cancer (10.4% of all cancer incidence, both sexes counted)[2] and the fifth most common cause of cancer death.[3] Worldwide, breast cancer is by far the most common cancer amongst women, with an incidence rate more than twice that of colorectal cancer and cervical cancer and about three times that of lung cancer. However breast cancer mortality worldwide is just 25% greater than that of lung cancer in women.[2] In 2005, breast cancer caused 502,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths).[3] The number of cases worldwide has significantly increased since the 1970s, a phenomenon partly blamed on modern lifestyles in the Western world.[4][5]

The incidence of breast cancer varies greatly around the world, being lower in less-developed countries and greatest in the more-developed countries. In the twelve world regions, the annual age-standardized incidence rates per 100,000 women are as follows: in Eastern Asia, 18; South Central Asia, 22; sub-Saharan Africa, 22; South-Eastern Asia, 26; North Africa and Western Asia, 28; South and Central America, 42; Eastern Europe, 49; Southern Europe, 56; Northern Europe, 73; Oceania, 74; Western Europe, 78; and in North America, 90.[6]

Women in the United States have the highest incidence rates of breast cancer in the world; 141 among white women and 122 among African American women.[7][8] Among women in the US, breast cancer is the most common cancer and the second-most common cause of cancer death (after lung cancer).[8] Women in the US have a 1 in 8 (12.5%) lifetime chance of developing invasive breast cancer and a 1 in 35 (3%) chance of breast cancer causing their death.[8] In 2007, breast cancer was expected to cause 40,910 deaths in the US (7% of cancer deaths; almost 2% of all deaths).[9]

In the US, both incidence and death rates for breast cancer have been declining in the last few years.[10][9] Nevertheless, a US study conducted in 2005 by the Society for Women’s Health Research indicated that breast cancer remains the most feared disease,[11] even though heart disease is a much more common cause of death among women.[12]

Because the breast is composed of identical tissues in males and females, breast cancer also occurs in males.[13][14] Incidences of breast cancer in men are approximately 100 times less common than in women, but men with breast cancer are considered to have the same statistical survival rates as women.[15]

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