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San Francisco, CA (PRWEB) November 09, 2011

Bristol-Myers Squibb Company (NYSE: BMY) today announced 96-week results from the BE‐LOW™ study, a Phase IIIb clinical trial comparing BARACLUDE monotherapy (0.5mg once daily) with BARACLUDE (0.5mg once daily) plus tenofovir (300mg once daily) in treatment-naïve adult patients with HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB) with compensated liver disease. In this study, no statistically significant difference was observed between the two treatment arms in the primary efficacy endpoint of HBV DNA

“In these 96-week data comparing entecavir monotherapy to combination of entecavir plus tenofovir, we found that combination therapy did not result in statistically significant difference in virologic response compared to entecavir monotherapy. The BE-LOW study data confirmed the results of previous studies showing limited or no benefit of combination therapy compared to monotherapy for treatment-naïve patients with chronic hepatitis B,” said principal investigator Anna Lok, MD, FRCP, director of clinical hepatology and professor in the department of internal medicine at the University of Michigan Medical School in Ann Arbor.

Study Results

In this study, 379 nucleos(t)ide-naïve patients with CHB were randomized to receive either BARACLUDE (entecavir) 0.5 mg once daily (n=182) or BARACLUDE 0.5 mg plus tenofovir 300 mg once daily (n=197). Key findings at week 96 are:

A comparable proportion of patients in both treatment arms achieved the primary efficacy endpoint of HBV DNA
Among HBeAg-positive patients, the proportion achieving HBV DNA
Among HBeAg-negative patients, the proportion achieving HBV DNA

Secondary efficacy endpoints measured in the study included alanine aminotransferase (ALT) normalization, HBeAg seroconversion, and HBeAg loss. ALT normalization was observed in 81.9% (149/182) of patients in this study in the BARACLUDE (entecavir) monotherapy arm versus 69% (136/197) in the BARACLUDE plus tenofovir arm. HBeAg seroconversion was observed in 32.5% (41/126) of patients in the BARACLUDE (entecavir) monotherapy arm versus 21.7% (30/138) in the BARACLUDE plus tenofovir arm in this study.

Two patients (1.1%) in the BARACLUDE monotherapy arm compared to five patients (2.5%) in the BARACLUDE plus tenofovir arm discontinued treatment prior to week 96. Patients who discontinued therapy prior to week 96 were considered treatment failures.

The overall adverse event profiles were similar across study arms. A total of three deaths occurred among treated patients, all on the BARACLUDE plus tenofovir arm: one due to bile duct tumor; one due to a late-onset exacerbation of hepatitis which was associated with breakthrough viremia while on continued treatment; and one due to cardiac arrest. One patient (0.5%) in the BARACLUDE monotherapy arm and two patients (1.0%) in the BARACLUDE plus tenofovir arm experienced on treatment ALT flares, defined as greater than 2 x baseline ALT and greater than 10 x ULN. No patients (0.0%) in either arm experienced off-treatment ALT flares. Six patients (3.3%) in the BARACLUDE monotherapy arm and four (2.0%) patients in the BARACLUDE plus tenofovir arm experienced serum creatinine increase ≥0.3 mg/dL. A total of five malignancies occurred among patients in the study: four (2.2%) patients in the BARACLUDE monotherapy arm and one (0.5%) patient in the BARACLUDE plus tenofovir arm. In the BARACLUDE monotherapy arm, there were three diagnoses of hepatocellular carcinoma (two on-treatment and one off-treatment) and one case of gastric cancer. In the BARACLUDE plus tenofovir arm there was one case of breast cancer.

Two patients (1.0%) in the BARACLUDE monotherapy arm and seven patients (3.6%) in the BARACLUDE plus tenofovir arm experienced virologic breakthrough. No recognized genotypic resistance mutations were observed in either treatment arm.

About The Study

The BE-LOW study is an open-label, multicenter, Phase IIIb study of 379 nucleos(t)ide-naïve patients with CHB. The patients were randomized 1:1 and treated with either BARACLUDE 0.5 mg once daily (n=182) or BARACLUDE 0.5 mg plus tenofovir 300 mg once daily (n=197). Nucleos(t)ide-naïve, HBeAg-negative CHB patient enrollment was capped at 30%. The primary efficacy endpoint was the proportion of patients with HBV DNA

About Chronic Hepatitis B

Approximately 350 million people worldwide are chronically infected with hepatitis B (approximately 5% of the world’s population) and 75% of these cases occur in the Asia-Pacific region.(2) Most people with chronic hepatitis B show no signs or symptoms, so many of those chronically infected are unaware of their status. A blood test can diagnose chronic hepatitis B. Patients should speak with their doctor about options available for this condition.

About BARACLUDE®

Discovered at Bristol-Myers Squibb, BARACLUDE® is indicated for the treatment of chronic hepatitis B virus (HBV) infection in adults with:

compensated liver disease and evidence of active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active inflammation and/or fibrosis

decompensated liver disease

For full prescribing information for BARACLUDE®, please consult the Summary of Product Characteristics.

About Bristol-Myers Squibb

Bristol-Myers Squibb is a global biopharmaceutical company committed to discovering, developing and delivering innovative medicines that help patients prevail over serious diseases.

BARACLUDE® (entecavir) is a registered trademark of Bristol-Myers Squibb Company.

Contacts:             

Bristol-Myers Squibb

Media: Annie Simond, +33 1 58 83 65 66, annie.simond(at)bms(dot)com

Note:

(1) HBV DNA carries the genetic blueprint of the hepatitis B virus. The number of HBV DNA “copies” found in a person’s blood, or “viral load,” indicates how rapidly the virus is reproducing in their liver. Low levels of HBV DNA, recognized as 300 copies per milliliter or less, indicate an “inactive” hepatitis B infection.

Reference:

(2) Hou J, Liu Z, Gu F. Epidemiology and Prevention of Hepatitis B Virus Infection. Int J Med Sci 2005; 2:50 – 57. Available from http://www.medsci.org/v02p0050.htm Accessed November 2011

###

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TBA
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Graham Cancer Center Expansion 8


Image by Christiana Care
June 2009: New construction has more than tripled the size of the Helen F. Graham Cancer Center to about 200,000 square feet. The expansion allows Christiana Care to include even more world-class cancer services and patient-centered care all in one location.

“The strategies we put in place have helped lower Delaware’s declining cancer rates and earned us national recognition as leaders in cancer care,” says Bank of America Endowed Medical Director Nicholas J. Petrelli, M.D. “With this new facility, we can take our fight against cancer to the next level.”

Bringing together the entire continuum of cancer care resources is the essence of the cancer program’s multidisciplinary approach. “Having all of a patient’s related cancer care services in one place facilitates interaction among specialists and promotes the transfer of knowledge about new technologies, drug regimens and treatments for cancer,” said Patrick Grusenmeyer, Sc.D., FACHE, senior vice president of Cancer and Imaging Services.

Accelerating cancer research

Among the most exciting aspects of the expansion is that it makes room for the Center for Translational Cancer Research , bringing advancements in the laboratory to the clinic, where they can help patients.

For patients, it means that doctors and scientists can collaborate closely and quickly. When a doctor discovers a new problem at the bedside, he is able to bring it to a scientist in the lab, where it can be analyzed, and a solution can be developed. The doctor can then bring the solution back to the bedside. This collaborative relationship creates the potential to make leaps forward in understanding and treating cancer in each individual patient.

“This move sets the stage for rapid advances in cancer stem cell biology and human cancer genetics,” said Robert Sikes, Ph.D., director of the Center for Translational Cancer Research and professor of biological sciences at the University of Delaware. “The Center for Translational Cancer Research begins a new chapter in a new space that allows for further synergy between the translational hub at the Helen F. Graham Cancer Center and the preclinical, basic science hub at University of Delware.”

More services, new technology

The expansion includes practice space for more surgeons, including gynecologic cancer surgeons, who can order diagnostic tests, perform biopsies to see if tumors are malignant and operate to remove cancer if necessary. It provides additional medical oncologists who can administer chemotherapy that kills cancer cells. And radiation oncologists who can pinpoint the places where cancer is growing and use precisely focused x-rays to reduce or destroy it.

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Catharanthus roseus Formerly known as VInca rosea

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[EDIT] – My wife adds that these alkaloids are known as Vincristine and Vinblastine.

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